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KMID : 0358420080510101112
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 10 p.1112 ~ p.1120
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The clinicopathological relevance for the expression of cyclin E, CDK2, and p27 in endometrial carcinoma
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Baek Yun-Ji
Chong Hye-In
Jang Ho-Jin
Suh Dong-Soo
Yoon Man-Soo
Choi Kyung-Un
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Abstract
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Objective: The aim of this study was to evaluate the clinicopathological relevance for the expression of cyclin E, CDK2 and p27 in endometrial carcinoma.
Methods: With a retrospective review, slide samples (n=71) were analyzed. All patients had been treated with hysterectomy from January 1998 to December 2006. The expression of cyclin E, CDK2 and p27 were analyzed using immunohistochemical staining.
Results: Of 71 cases, the positive expression was cyclin E; 28 cases (39.4%), CDK2; 29 cases (40.8%). The expression of cyclin E showed positive correlation with lymph node metastasis (P=0.033) and estrogen receptor. The expression of CDK2 showed positive correlation with estrogen receptor (P=0.000). The negative expression of p27 was 42 cases (59.2%) and showed no correlation with other clinicopathological factors. Cyclin E overexpression with loss of p27 expression showed positive correlation with advanced stage (P=0.002), lymphovascular invasion (P=0.030) and lymph node metastasis (P=0.002).
Conclusion: Cyclin E overexpression with loss of p27 expression could be an useful negative prognostic factors for endometrial carcinoma.
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KEYWORD
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Cyclin E, CDK, p27, Endometrial carcinoma
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